蛋白酶切位点.docx

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1、EnZYmeSE.C.NumberCleavagesitesSerineproteases（丝石酸蛋白酸）E.C.3.4.21.-chymotrypsin（S喷乳蜜白酱,糜蛋白鲍E.C.3.4.21.1Tyr-Xaa,Trp-Xaa,Phe-Xaa,andalso1.eu-aa,Met-aa,Trypsin（三三,胰蛋白房）E.C.3.4.21.4Arg-Xaa,1.ys-Xaa,Pancreaticelastase（胰弹性蛋白酶）E.C.3.4.21.36Ala-Xaa,adalsoGly-Xaa,Val-Xaa,Ser-Xaa,ThrOmbin（凝血酹）E.C.3.4.21.5Arg-Gl

2、y,PIaSmin（胞质素，胞浆素）E.C.3.4.21.71.ys-Xaa,Arg-XaaProlyloligopeptidase,orprolylendopeptidaseE.C.3.4.21.26Plasmakallikrein（血浆激肽释放酶）E.C.3.4.21.34Arg-Xaa,1.ys-Xaa,includingArg-Ser,1.ys-Arg,1.eukocyteelastase（白细胞弹性蛋白的）,orneutroPhileIaStaSe（中性白细胞弹性蛋白S）,odysoSomaIelaStaSe（溶能体弹性蛋白醐E.C.3.4.21.37VaIT-Xaa,Ala-Xaa

3、zCysteineproteases（半胱夙酸蛋白酶）E.C.3.4.22.CathepsinB（组织蛋白酶）E.C.3.4.22.1Arg-Arg-Xaa,andalso1.eu-Xaa,Ala-Xaa,Phe-Xaa,Trp-Xaa,Clostripain（梭菌蛋白前）,orendoproteinaseArg-CE.C.3.4.22.8Arg-aaincludingArg-Pro,butnot1.ys-XaaCaIPain（钙激活中性蛋白的）-1QrlJ-CalPainE.C.3.4.22.52Met-Xaa,Tyr-XaaandArg-Xaa（with1.euorVaIastheP2re

4、sidue）Asparticacidproteases（天冬氨酸蛋白酶）E.C.3.4.23.PePSin（宵阮酹,目蛋白酶）E.C.3.4.23.1PreferentiallyPhe-aa,Tyr-Xaa,Andalso1.eu-Xaa,andTrp-Xaa,ideallywithXaa=Phe1Trp1OrTyrCathePSin（组织蛋白酶）DE.C.3.4.23.5PreferentiallyPhe-aa,Tyr-Xaa,Andalso1.eu-Xaa,ideallywithXaaAIaorVaIMetalloproteases（金属蛋白前）E.C.3.4.24.NePrilysin（

5、脑琲肽蚓,orenkephalinase（B啡肽博）,orneutralendopeptidaseE.C.3.4.24.11Xaa+Tyr,Xaa+Phe,Xaa-Trp,adXaa-1.eu,ThimetoligoPePtidase（甲拌磷寡肽S5）,orendo-oligopeptidaseA,orendopeptidase（肽造内切箭）24.15,orPZ-PePtideaSe眼促胰褥素）E.C.3.4.24.15Xaa-1-Arg,Xaa-Ser,Xaa-Ile,Xaa-Ala,Xaa-Gly,Aminopeptidases（氮5）E.C.3.4.11.N-termIeUCyI-ami

6、nopeptidaseE.C.3.4.11.1Preferentially1.eu-Xaa,butnotArg-aa,and1.ys-aa,AminopeptidaseMorN,oralanylaminopeptidase。membranealanineaminopeptidaseE.C.3.4.11.2PreferentiallyAla-Xaa,andTyr-aa,ifYaa-Pro-I-XaaintermwithYaa=AlazVal1.eu1IIe1Phe1TyrorTrp,thenthedipeptideYaa-ProcouldbereleasedAminopeptidaseBE.C.

7、3.4.11.6Arg-aa,1.ys-Xaa,AminopeptidaseA1Orangiotensinase,orglutamyl-aminopeptidaseE.C.3.4.11.7Glu-XaaAsp-Xaa,Dipeptidyl-peptidasesandtripeptidyl-peptidases(二肽基肽能和三肽基肽酶)E.C.3.4.14.N-term(di-andtripeptides)Dipeptidyl-peptidasel,orCathePSin(组织蛋白陶)CorJE.C.3.4.14.1aa-Yaa-Zaa,ifXaaxArgor1.ys,orYaaProforZa

8、aProDipeptidyl-peptidaseIVE.C.3.4.14.5Preferentiallyaa-Pro-Zaa,(butalsoXaa-Ala-Yaa)withYaaProorHypProlyltripeptyl-peptidaseE.C.3.4.14.12Xaa-Yaa-Pro-I-ZaaJfZaaProPeptidyl-Dipeptidases（肽基-ZZttSS）E.C.3.4.15.C-termPeptidyl-depeptidaseA,orangiotensin-convertingenzymeE.C.3.4.15.1Xaa-Yaa-Zaa,ifYaaProorZaaA

9、sporGluMetallo-Carboxypeptidases（金霹JW）E.C.3,4.17.C-termCarboxypeptidaseAE.C.3.4.17.1Xaa-YaaifYaaAsp1GIulArgj1.ysorProCarboxypeptidaseB,orprotaminaseE.C.3.4.17.2Xaa-Argandaa-1.ysCarboxypeptidaseN,or1.ysine（arginine）,CarbOXyPePtidaSe（段基肽酶）,orkininase1（激肽房）E.C.3.4.17.3Xaa-1.ysXaa-ArgCarboxypeptidaseUorRE.C.3.4.17.20Xaa-ArgandXaa-1.ysGlutamateCarboxypeptidasen,orfolatehydrolaseE.C.3.4.17.21aa-Glu,preferentiallywithXaa=AsporGlu