人活体小肠移植受体血清IL┐8与排斥反应相关.docx

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1、人活体小肠移植受体血清I1.n8与排斥反应相关I1.8-:;/;8;:11.-8E1.ISA1140dI1.-8.I1.-81d2.44g1.-1.vsO.26g1.-11.70g1.-14d.I1.-8267d1.47g1.-11196d.I1.-8.Keywords:Iivingdonnors;intestinesma1.!/transp1.antation;inter1.eukin-8;graftrejectionAbstractIA1.MToinvestigatetheperioperativeserum1.ev-e1.sofI1.-8inthefirstcaseofIiving-re

2、1.atedsma1.Ibowe1.transp1.antationinChiIiaandtostudytheinterre1.ationshipofthechangesinserum1.1.-81eve1.withischemicandreperfusiveinjuryandwiIhtheacutesma1.Ibowe1.a1.Iograftrejection.METHODSDynamicserum1eveIsof1.1._8ofrecipientwereana1yzedbyasoIid-PhaSedOUbIe1.igandE1.1.SAmethOdonCePreOPeratiOnandSe

3、Vera1.timesduring1.HOdpostoperation.RESU1.TSRecipientsI1.8serun1.eve1.increasedonIpostoperatiordayP0D2.44g1.-1.vsO.26g1.-1de-creasedrapid1ythenextday1.70g1.-Iandreturnedtothe1.eve1.ofpreoperationat4P0D.1tssecondpeak1.eve1.oc-curredon671,0Dwithacutesma1.Ibowe1.a1.Iograftrejection1.47g1.-1.Thenitdecre

4、aseds1.ow1.yandreturnedtothe1.eve1.ofpreoperationony6P0D.CONC1.USIONInthehu-man1iving-reIatedsma1.Ibowe1transp1.antationthereisacIosecorreIationofserum1.1.-S1.eve1.swithiSchemicandrepcrfusivcinjuryandwiththeacutesma11boweIa1.Iograftre-jection.Itcou1.dberegardedasoneofthemostimportantsignsofacutesma1

5、.Ibowe1.a1.Iograftrejection.O1I1.-1I1.-6TNF-.I1.-82-45.adu1.trespiratorydis-tresssyndromeARDSbowe1.-associated1.ymphoidtissueB1.TI1.8268.E1.ISAI1.-8.1999-05-201.a.I1.-8.11.118.1998-0940cm10.1999-03-10182cm35kg.44.OH1.ADR.-1999-05-20.150cm.20cm.15cmIOcm10cm.5min.10h1.min215min.IdMMF2g.500mgEIPGE11OOg

6、FK5065mg500mg.FK5062535g1.-1.:.-9.30d.60d66d1.200m1.67d:：.:-.Fig1.2.:500mgId-I3dFK5067mg2d-12025g1.-12gd-1.70dFig3.D-:30.7%.82c1.1-31.2E1.ISI1.-8.I1.-8mAhmbmAbABTSAODI1.-8.2I1.-80.26g1.-1.Id1.I1.-82.44g1.-1.4d.2I1.-867d1.47g1.-11I1.-860%.96dFig4.3 .10.4 .I1.-811.I1.-8:.I1.-8;.GM-CSFI1.-5;T.CD4+CD8+T

7、.I1.-8I1.-2NK;I1.-8/TI1.-8.I1.-8.112-I1.-8ACI-I-EWBN-1.EW;I1.-6I1.-8.13-16E1.ISA:I1.-8I1.-8UTIUTII1.-8;-O1.TxI1.-8CMVI1.-8O1.Tx.I1.-81Id1.min215min1.718.I1.-82d4d.267dI1.-817d.I1.-8.I1.-8I1.-8:IYagihashiZouXMHirataKAsanumaKTsurrumaTMatunoTYamaguchi1.1.YamashiroKKoidcSTcrimotoK.Eva1.uationofseruiii1.

8、1.-Sconcentrationsafterorthotopic1.iv-ertranspantationinratsJ.Transp1antProc1995;272:1632-1633.2SekidoXMudaidaNHaradaNakamishiIWatanabeYMatsushimaK.Prevcntionof1.ungreperfusioninjuryinrabbitbyamonoc1onaIantibOdyagainstinterIeukin_8J.Nature1993;3656477:654-657.3HaradaSekido)unoKkiyamaMKasaharaTNakani

9、shiIMukaidaNMatsushimaK.Expressionofrecom-binantrabbitI1.-8inEschcrichiaco1iandestab1ishmentoftheessentia1.invo1.vementofI1.-SinrecruitingneutrophiIsinto1.ipopo1.ysaccharide-inducedinf1.ru11matorysitofrabbi1.skinJ.IntImmuno1.1993;56:681-690.4ChenJKZhuY1.WangGFZhangQHRenXDMeiQZhangWH.Studyofiininunor

10、eactiveinter1.eukin-Sinthegastricmucosa1.ce1.Iofstressandindomethaci11-induceduIcerratsJ.191:76-79.Di-SijunyiDaxueXuebaoJFourthMiIMedUniv1998;5)onnc)IyscstrictcrRMKunkeis1.wa1.zARobcrtsonCRCarterDCGrantISPo1.1.okJHas1.ettC.Inter1.eukin-Sanddeve1.opnicntofdu1.trespiratorydistresssyndronieinat-riSkpat

11、ientgroupsJ.1.ancet1993;3418846:643-647.6ChenJKZhuY1.7hangWHZhaoYFZhongYQChaoYXWangYK.ExistenceanddistributionofI1.8Rim-munopositiVece1.1.sindigestivetractofratsj.Di-SijunyiDaxueXuebaoJFourthMiIMedUniv2000;214:440-442.7Baggio1iniMWaIzAKunke1.S1.NcutrophiI-activatingpep-tide-1/inter1.eukin-8anovcIcyt

12、okinethatactivatesneutrophiIsJ.JC1.inInvest1.989:844:1045-1019.8f)avenportRDStrietcrRMStandifordTJKunke1.S1.Ubr-wekwyjin-8productioninredb1oodceI1.incompatibi1ityj.B100d1990;7612:2439-2442.9DingJ1.iCNWangWZSongW1.wUGS.EndoscopicmonitoringofhumansmaI1.intestina1.vivotransp1.antationJ.Di-SiJunyiDaxueX

13、uebaoJFourthMiMedUniv2000;212:158-159.1OWangGSunXYWeiMF.Sma11boweItransp1.antation.In:SuZXYu1.XHuangJF.XiandaiyizhiXueModemtransp1.antationM.Beijing:RenmingWeiShengChubanshePeop1eSHea1.thPub1.ishi11gPress1.998:616-652.11WatanabeKKoizumiFKurashigeYTsurufujiSNakagawaH.ReitciNCamemberofthcinter1.eukin-

14、8famiIyiSaneU-1rophi1-specifiCchemoattractantinvivoj.ExpMo1.Patho1.1991;551:30-37.12BorosPSuchiroTCurtiSSSSheinerPEmreSGUySSChWartZMEMi11.erCM.Differentia1.contributionofgraftandrecipienttoperioperativeRNF-I1.-II1.-Gand1.1.-S1.eve1.andcorre1.ationwithear1.ygraftfunctioninc1.inica1.1ivertrans-pIantat

15、ionJ.C1.inTransp1.ant1.997;116:588-592.13SibbringjSSharmaAMcDichenIWSe11sPChristmasSE.1.oca1.izationofC-X-CandC-Cchemokinestorena1.tubu1.arepiIhe1.ia1.Ce1.1.sinhumankidneytransp1.antsisnotconfinedtoacutece1.1.u1.arrejectionj.Transp1.Immuno1.1998;64:203-208.HBoratynskaM.Monitoringofinter1.eukin-Sinur

16、ineandinserumofpatientsafterkidneytransp1.antationj.Przeg1.1.ek1998;5511:576580.15TiIgHCeSkaMBOgeINHerOIdMMargreiterRHuberc.Inter1.eukin-Sserumconcen1.rationsafter1.iVertransp1.antationJ.Transp1.antation1992;534:800803.1OWanS1.eC1.ercJ1.AntoIneMDeSmetJMYimPVinccntj1.,.Heparin-Coatedcircuitsreducemyoca