胃肠道间质瘤.ppt

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123456789 1011121314151617Epithelioid cell typeSpindle cell type181920c-kit proto-oncogene定位定位4q11-21编码编码CD117（145kDa，SCF受体）受体）属酪氨酸激酶家族属酪氨酸激酶家族 2122CD11723CD1172425262728间质瘤良恶性诊断标准为：间质瘤良恶性诊断标准为：293031Gleevec(Glivec;STI571)therapy3233A 4 cm mass mainly seen in the submucosa and muscularis propria;focal mucosal ulceration34The mucosa is largely spared35Spindle cell proliferation with moderate cellularity36Diffusely and strongly positive for c-kitDiffusely and strongly positive for c-kit37DIAGNOSIS3839404142诊断诊断43VIM（+），），44S-100（+）45CD117（）46免疫组化标记免疫组化标记47最后诊断最后诊断