多发性肌炎和皮肌炎的诊治进展.ppt

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概要 GottronGottron征甲小皮增厚，甲皱襞僵直毛细血管扩张A 化脓性炎症办钙质沉着（箭头）B X线平片示皮下或肌内钙质沉着NEJM Oct 12,1995 P978IBM患者，早期出现指屈肌（C）和指伸肌（D）受累。总体来说，DM伴肿瘤发生率要高于PMPM中T细胞穿过细胞壁并识别肌纤维抗原过程中涉及的分子、受体和配体MHC-类分子过度表达肌纤维血管数量减少，残余血管代偿性扩张肌纤维血管数量减少，残余血管代偿性扩张DM晚期毛细血管正常毛细血管CD8+T细胞侵犯表达MHC-肌纤维(橙色)5 refractory PM/DM patients with ILD including CsA，treated with FK506；3 improved promptly,1 gradually and steadily,and another case responded slowly after prednisolone dose was increased.None developed adverse effects