boldmri与脂肪肝.docx

boldmri与脂肪肝yyCarbogenGasChallengeBOI.DMRImaginginaRatModelofDiethylnitrosamine-induced1.iverFibrosis1.NingJin,MS,2.JieDeng,PhD,3.TamunaChadashvi1i,PhD,4.YueZhang,BS,5.YangGuo,MD,6.ZhuoliZhang,MD,7.Guang-YuYang,MD,PhD,8.Reed.Omary,MDand9.AndrewC.1.arson,PhD+AUthOrAffiliations1.1l'romtheDepartmentsofRadiology(N.J.,J.D.,T.C.,Y.Z.,Y.G.,Z.Z.,R.O.,A.C.1.),BiomedicalEngineering(N.J.,J.D.,R.A.O.,.C.1.),andPathology(G.Y.Y.),andRobertII.1.urieComprehensiveCancer(R.A.O.,.C.1.),NorthwesternUniversity,737NMichiganve,Suite1600,Chicago,I1.60611;DepartmentofMedicalImaging,ChildrensMemorialHospital,Chicago,Ill(J.D.);andDepartmentofBioengineering,UniversityofIllinoisatChicago,Chicago,Ill(Y.Z.).1.AddresscorrespondencetoA.C.1.(e-mai1:aTarsonnorthwestern.edu).1.Authorcontributions:Guarantorsofintegrityofentirestudy,Z.Z.,.C.1.;studyconcepts/studydesignordataacquisitionordataanalysis/interpretation,allauthors;manuscriptdraftingormanuscriptrevisionforimportantintellectualcontent,al1authors;manuscriptfinalversionapproval,allauthors:literatureresearch,N.J.,J.D.,T.C.,Y.Z.,Y.G.,Z.Z.,.C.1.;experimentalstudies,al1authors;statisticalanalysis,N.J.,J.D.,Y.Z.,Y.G.,Z.Z.;andmanuscriptediting,N.J.,J.D.,Y.Z.,Y.G.,Z.Z.,G.Y.Y.,A.C.1.NextSectionAbstractPurpose:Toinvestigatetherelationshipbetweengas-chalIengeb1oodoxygenIeveldepcndcnt(BO1.D)magneticresonance(MR)imagingmeasurementsandhepaticdiseaseprogressioninaratmode1ofdiethylnitrosamine(DEN)-induced1iverfibrosis.MaterialsandMethods:Theinstitutionalanimalcareandusecommitteeapprovedal1experiments.1.iverfibrosiswasinducedin27maleWistarratsbymeansofweeklyoralgavagewith5m1.of1.5%DENsolutionperkiIogramofbodyweightfor311weeks,whichproducedvaryingdegreesof1iverfibrosis.Eightratsdevelopednonsubstantialfibrosis(非物质性的.